Vale Lab Publications (1979-1995)

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  • (pdf) - Coppin, C.M., Finer, J.T., Spudich, James A. and Vale, R..D. (1995) Measurement of the isometric force exerted by a single kinesin molecule. Biophys J 68: 242s-244s.
  • (pdf) - Hoenger, A., Sablin, E.P., Vale, R.D., Fletterick, R., and Milligan, R.A. (1995) Three-dimensional structure of a tubulin-motor protein complex. Nature 376: 271-274.
  • (pdf) - Shimizu, T., Sablin, E., Vale, R.D., Fletterick, R., Petchatnikova, E. and Taylor, E.W. (1995) Expression, purification, ATPase and microtubule binding properties of the ncd domain ADP release is the rate limiting step in the microtubule-stimulated ATPase pathway. Biochem 34: 13259-13266.
  • (pdf) - Shimizu, T., Toyoshima, Y.Y., Edamatsu, M. and Vale, R.D. (1995) Comparison of the motile and enzymatic properties of two microtubule minus-end-directed motors, ncd and cytoplasmic dynein. Biochem 34: 1575-1582.


  • (pdf) - Malik, F., Brillinger, D. and Vale, R.D. (1994) High resolution tracking of microtubule motility produced by single kinesin motors. Proc Natl Acad Sci USA 91: 4584-4588.
  • (pdf) - Niclas, J, Navone, F, Hom-Booher, N. , Vale, R.D. (1994) Cloning and localization of a conventional kinesin motor expressed exclusively in neurons. Neuron 12: 1059-1072.
  • (pdf) - Vale, R.D. (1994) Getting a grip on myosin. Cell 78: 733-737.
  • (pdf) - Vale, R.D., Coppin, C.M., Malik, F., Kull, F.J. and Milligan, R.A. (1994) Tubulin GTP hydrolysis influences the structure, mechanical properties and kinesin-driven transport of microtubules. J Biol Chem 269: 23769-23775.


  • (pdf) - McNally, F. and Vale, R.D. (1993) Identification of katanin, an ATPase that severs and disassembles stable microtubules. Cell 75: 419-429.
  • (pdf) - Romberg, L. and Vale, R.D. (1993) Chemomechanical cycle of kinesin differs from that of myosin. Nature 361: 168-170.
  • Scholey J.M. and Vale, R.D. (1993) Kinesin based organelle transport. In: Microtubules (J.S. Hyans and C.W. Lloyd, eds.) John Wiley & Sons, pp. 343-365.
  • Shimizu, T., Toyoshima, Y.Y., Vale, R.D. (1993) Use of ATP analogs in motor assays. Meth Cell Biol.39: 167-177.
  • (pdf) - Vale, R.D. (1993) Measuring single motor proteins at work. Science 260: 169-170.
  • Vale, R.D. (1993). Motor proteins. In: Guidebook to Cytoskeletal and Structural Proteins. (R. Vale and T. Kreis, eds.) Oxford University Press, pp. 175-183.
  • (pdf) - Wilhelm, J. and Vale, R.D. (1993) RNA on the move: The mRNA localization of pathway. J Cell Biol 123: 269-274.
  • (pdf) - Allan, V. and Vale, R.D. (1994) Movement of membrane tubules along microtubules in vitro: evidence for specialized sites of motor attachment. J Cell Sci 107: 1885-1897.


  • (pdf) - Ferreira, A., Niclas, J., Vale, R.D., Banker, G. and Kosik, K.S. (1992) Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides. J Cell Biol 117: 595-606.
  • (pdf) - Goldstein, L.S.B. and Vale, R. (1992) New cytoskeletal liasons. Nature 359: 193-194.
  • (pdf) - Navone, F., Niclas, J., Hom-Booher, N., Sparks, L., Bernstein, H., McCaffrey, G.M., and Vale, R.D. (1992) Cloning and expression of a human kinesin heavy chain gene: Interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. J Cell Biol 117: 1263-1275.
  • Vale, R.D. (1992). Microtubule motors: many new models off the assembly line. Trends Biol Sci 17: 300-304.
  • Vale, R.D., Banker, G. and Hall, Z.W. (1992) The neuronal cytoskeleton. In: An Introduction to Molecular Neurobiology. (Z.W. Hall, ed.). Sinauer Associates, Inc., Sunderland, MA, pp. 247-280.
  • (pdf) - Vale, R.D., Malik, F. and Brown, D. (1992) Directional instability of microtubule transport in the presence of kinesin and dynein, two opposite polarity microtubule motor proteins. J Cell Biol 119: 1589-1596.
  • Vale, R.D., Radeke, M.J., Misko, T.P. and Shooter, E.M. (1992) The nerve growth factor receptors. In: Receptor Subunits and Complexes. (e.d. A. Burgen and E.A. Barnard). Cambridge University Press, Cambridge, U.K., pp. 391-417.


  • (pdf) - Allan, V. and Vale, R.D. (1991) Cell cycle control of microtubule-based membrane transport and tubule formation in vitro. J Cell Biol 113: 347-359.
  • Allan, V.J., Vale, R.D. and Navone, F. (1991) Microtubule-based organelle transport in neurons. In: The Neuronal Cytoskeleton, (R.D. Burgoyne, ed.) Alan R. Liss, Inc., pp. 257-282.
  • (pdf) - Goldstein, L.S.B. and Vale, R.D. (1991) A brave new world for dynein. Nature 352: 569-570.
  • (pdf) - Schliwa, M., Shimizu, T., Vale, R.D. and Euteneuer, U. (1991) Nucleotide specificities of anterograde and retrograde organelle transport in Reticulomyxa are indistinguishable. J Cell Biol 112: 1199-1203.
  • (pdf) - Shimizu, T., Furusawa, K., Ohashi, S., Toyoshima, Y.Y., Okuno, M., Malik, F. and Vale, R.D. (1991) Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin and heavy meromyosin. J Cell Biol 112: 1189-1197.
  • (pdf) - Vale, R.D. (1991) Severing of stable microtubules by a mitotically-activated protein in Xenopus egg extracts. Cell 64: 827-839. (cover)


  • (pdf) - Malik, F. and Vale, R. (1990) A new direction for kinesin. Nature 347: 713-714.
  • Vale, R.D. (1990). Microtubule-based motors. Curr Opin Cell Biol 2: 15-22.
  • (pdf) - Vale, R.D. and Goldstein, L.S.B. (1990) One motor, many tails: an expanding repertoire of force-generating enzymes. Cell 60: 883-885.
  • (pdf) - Vale, R.D. and Oosawa, F. (1990) Protein motors and Maxwell's demons: does mechanochemical transduction involve a thermal ratchet? Adv Biophys 26: 97-134.


  • (pdf) - Howard, J., Hudspeth, A.J. and Vale, R.D. (1989) Movement of microtubules by single kinesin molecules. Nature 342: 154-158.
  • (pdf) - McCaffrey, G. M. and Vale, R.D. (1989) Identification of a kinesin-like microtubule-based motor protein in Dictyostelium discoideum. EMBO J 8: 3229-3234. PMCID: PMC401445.
  • (pdf) - Vale, R.D., Soll, D.R., and Gibbons, I.R. (1989) One-dimensional diffusion of microtubules bound to flagellar dynein. Cell 59: 915-925.
  • (pdf) - Vale, R.D. and Toyoshima, Y.Y. (1989) Microtubule translocation properties of intact and proteolytically digested dyneins from Tetrahymena cilia. J Cell Biol 108: 2327-2334.


  • Vale, R.D. (1988) Microtubule-based mobility proteins and sorting of vesicles in neurons. In: Molecular Mechanisms in Secretion (N.A. Thorn, M. Treiman, O.H. Petersen, eds.) Alfred Benzon Symposium 25, Munksgaard, Copenhagen, pp. 397-406.
  • (pdf) - Vale, R.D. and Hotani, H. (1988) Formation of membrane networks in vitro by kinesin-driven microtubule movement. J Cell Biol 107: 2233-2241.
  • (pdf) - Vale, R.D. and Toyoshima, Y.Y. (1988) Rotation and translocation of microtubules in vitro induced by dyneins from Tetrahymena cilia. Cell 52: 459-469. (cover)
  • Vale, R.D. and Toyoshima, Y.Y. (1988) In vitro motility assays for kinesin and dynein. In: Cell Movement (F.D. Warner and J.R. McIntosh, eds.) Alan Liss, Inc., Vol. 2, pp. 287-294.
  • Vale, R.D. and Toyoshima, Y.Y. (1988) In vitro translocation properties of ciliary dyneins. In: Dynamics of Microtubules; Proceeding of the 14th Taniguchi International. Symposium, Division of Biophysics (H. Hotani, ed.) The Taniguchi Foundation. pp. 2-16.


  • (pdf) - Porter, M.E., Scholey J.M. , Stemple, D.L., Vigers, G.P.A., Vale, R.D., Sheetz, M.P. and McIntosh, J.R. (1987) Characterization of microtubule movement produced by sea urchin egg kinesin. J Biol Chem 262: 2794-2802.
  • Sheetz, M.P., Vale, R.D., Schnapp, B.J., Schroer, T. and Reese, T.S. (1987) Movements of vesicles on microtubules. New York Acad Sci 493: 409-416.
  • (pdf) - Vale, R.D. (1987) Intracellular transport using microtubule-based motors. Ann Rev Cell Biol 3: 347-378.


  • (pdf) - Schnapp, B.J., Vale, R.D., Reese, T.S. and Sheetz, M.P. (1986). Microtubules and the mechanism of directed organelle movement. New York Acad Sci 466: 909-918.
  • Sheetz, M.P., Vale, R., Schnapp, B., Schroer, T. and Reese, T. (1986) Vesicle movements and microtubule-based motors. J Cell Sci 5: 181-188.
  • Vale, R.D., Scholey J.M. and Sheetz, M.P. (1986) Kinesin: possible biological roles for a new microtubule motor. Trends in Biochem Sci 11: 464-468.


  • Vale, R.D., Hosang, M. and Shooter, E.M. (1985). Sialic acid residues on NGF receptors on PC12 cells. Dev Neurosci 7: 55-64.
  • (pdf) - Vale, R.D., Ignatius, M.J. and Shooter, E.M. (1985) Association of nerve growth factor receptors with the Triton X-100 cytoskeleton of PC12 cells. J Neurosci 5: 2762-2770.
  • (pdf) - Vale, R.D. and Shooter, E.M. (1985) Assaying binding of nerve growth factor to cell surface receptors. Meth Enzym 109: 21-39.
  • (pdf) - Vale, R.D., Schnapp, B.J., Sheetz, M.P. and Reese, T.S. (1985) Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon. Cell 40: 449-454. (cover)
  • (pdf) - Schnapp, B.J., Vale, R.D., Sheetz, M.P. and Reese, T.S. (1985) Single microtubules from squid axoplasm support bidirectional movement of organelles. Cell 40: 455-462.
  • (pdf) - Vale, R.D., Schnapp, B.J., Reese, T.S. and Sheetz, M.P. (1985) Organelle, bead and microtubule translocations promoted by soluble factors form the squid giant axon. Cell 40: 559-569.
  • (pdf) - Vale, R.D., Reese, T.S. and Sheetz, M.P. (1985) Identification of a novel force generating protein, kinesin, involved in microtubule-based motility. Cell 42: 39-50. PMCID: PMC2851632.
  • (pdf) - Vale, R.D., Schnapp, B.J., Mitchison, T., Steuer, E., Reese, T.S. and Sheetz, M.P. (1985) Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro. Cell 43: 623-632.
  • Vale, R.D., Schnapp, B.J., Mitchison, T., Reese, T.S. and Sheetz, M.P. (1985) Kinesin: a novel microtubule-based force generating protein. In: Microtubules and Microtubule Inhibitors (M. DeBrabander and J. DeMey, eds.). Vol. 3, 213-224.


  • Sutter, A., Hosang, M., Vale, R.D. and Shooter, E.M. (1984) Interaction of nerve growth factor and its specific receptor. In: Cellular and Molecular Biology of Neuronal Development (I.B. Black, ed.). Plenum Press, New York, pp. 201-214.
  • (pdf) - Vale, R.D., Peterson, S.W., Matiuck, N.V. and Fox, C.F. (1984) Purified plasma membranes inhibit polypeptide-induced DNA synthesis in subconfluent 3T3 cells. J Cell Biol 98: 1129-1132.
  • (pdf) - Vale, R.D., Szent-Györygi, A. and Sheetz, M.P. (1984) Movement of scallop myosin on Nitella actin filaments: regulation by calcium. Proc Natl Acad Sci USA 81: 6775-6778.


  • Vale, R.D., Chandler, C.E., Sutter, A. and Shooter, E.M. (1983) Binding and internalization of nerve growth factor. In: Receptors and Recognition (P. Cuatrecasas and T. Roth, eds.). Series B, Vol. 15, pp. 83-118.
  • (pdf) - Vale, R.D. and Shooter, E.M. (1983) Conversion of nerve growth factor receptor complexes to a slowly dissociating, Triton X-100 insoluble state by anti-nerve growth factor antibodies. Biochem 22: 5022-5028.
  • (pdf) - Vale, R.D. and Shooter, E.M. (1983) Epidermal growth factor receptors on PC12 cells: alteration of binding properties by lectins. J Cell Biochem 22: 99-109.


  • Peterson, S.W., Lerch, V., Moynihan, M.E., Carson, M.P. and Vale, R. (1982) Partial characterization of a growth inhibitory protein in 3T3 cell plasma membranes. J Exp Cell Res 142: 447-451.
  • (pdf) - Vale, R.D., DeLean, A., Lefkowitz, R.J. and Stadel, J.M. (1982) Regulation of insulin receptors in frog erythrocytes by insulin and concanavalin A: evidence for discrete classes of insulin binding sites. Mol Pharm 22: 6 19-629.
  • (pdf) - Vale, R.D. and Shooter, E.M. (1982) Alteration of binding properties and cytoskeletal attachment of nerve growth factor receptors in PC12 cells by wheat germ agglutinin. J Cell Biol 94: 710-717.


  • Fox, C.F., Vale, R., Peterson, S.W. and Das, M. (1979). The EGF receptor: identification and functional modulation. In: Cold Spring Harbor Conferences on Cell Proliferation. Vol. 6, Book A, pp. 143-158.
  • Fox, C.F., Wrann, M., Linsley, P. and Vale, R. (1979) Hormone-induced modification of EGF receptor proteolysis in the induction of EGF action. J Supramol Struct 12: 517-531.