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COVER:

Artistic rendering of dynein motor proteins moving along microtubules, based on a crystal

structure reported by Carter et al. on p. 1159. This study reveals the architecture of the molecular

machine that powers the beating of cilia and intracellular transport and provides insight into the

mechanism by which energy from adenosine triphosphate hydrolyss is converted into motion.

Image: Graham Johnson, The Scripps Research Institute and grahamj.com